3,14,17-Substituted-6,7-tetramethylenemorphinans

ABSTRACT

3,14,17-Substituted-6,7-Tetramethylenemorphinans have been found to possess potent narcotic agonist and/or antagonist activity. In particular, the compounds l-17-cyclopropylmethyl-3,14 Alpha (and14 Beta )-dihydroxy-6,7-tetramethylenemorphinan have been found to possess potent narcotic antagonist activity. These compounds are prepared by total synthesis and are not derived from opium alkaloids.

United States Patent 1 Menard et al.

[ Oct. 7, 1975 l 54 l 3,14,17-SUBSTlTUTED-6J-TETRAME- THYLENEMORPHINANS [75] inventors: Marcel Menard, Candiac; Pierre Rivest, Montreal. both of Canada [73] Assignee: Bristol-Myers Company, New York,

221 Filed: Nov. 7, 1973 21 Appl. No.: 413,464

[52] U.S. CL. 260/285; 260/240 AL; 260/2475 GP; 260/5708 R; 260/5708 TC; 260/590, 424/260 [51] Int. Cl. C07D 221/38; C07D 49l/08; A61 K 3 U485 [58] Field of Search 260/285 [56] References Cited UNITED STATES PATENTS 3,775.4l4 ll/l973 Monkovic et al 260/285 3,8l9,635 6/1974 Pachtcr et al 260/285 Primary Examiner-Donald G. Daus Assistant Examiner-Diana G. Rivers Attorney, Agent, or Firm-Robert E. Havranek [57] ABSTRACT 21 Claims, N0 Drawings l 3,14,l7-SUBSTITUTED-6,7-TETRAME- THYLENEMORPHINANS BACKGROUND OF THE INVENTION 1. Field of the invention:

This invention embodies new and novel compounds useful as analgesics and/or narcotic antagonists and a new and novel total synthesis for their preparation.

2. Description of the Prior Art:

A. Everette May and Hiroshi Kugita. J. Org. Chem. 26, l88 (1961). describe compounds having the formula in which R is H or methyl and R is methyl or phenethyl as being moderate to weak analgetics.

B. Everette May, Hiroshi Kugita and .1. Harrison Ager, J. Org. Chem. 26, 162] (l96l), report compounds having the formula in which R is methyl or phenethyl, R is methyl or H, R is H, OH or methoxy as producing varying degrees of analgesia.

C. Everette May, Colin Chignell and J. Harrison Ager, J. Med. Chem. 8. 235 I965), report compounds having the formula in which R is H or methyl and R is methyl as possessing analgctic activity.

D. Everette May and Seiichi Sato. J. Org. Chem. 26. 4536 (1961 report compounds having the formula N-CH3 3 11 wherein R represents a hydrogen atom or a lower alkyl, R represents a hydrogen atom. an aryloxy or a substituted aryloxy and X is hydrogen or OH as having analgetic activity.

G. Yoshiro Sawa, Naoki Tsuzi and Haruhiko Toda, US. Pat. No. 3,201.403. report the compounds having the formula wherein R is lower alkyl, R is H or aryloxy. R" and R' each represent a methylene group or a ketalatcd carbonyl group or a carbonyl group. X represents H or OH and Y represents a lower alkyl an aryl or an aralkyl group as possessing analgesic, antitussive and antiinflammatory activity.

H. Sawa and Tsuzi, US. Pat. No. 3230224. report the compounds having the formula ROR' in which R is lower alkyl, R is H, aryloxy, lower alkoxy, nitro or amino, R" and R' each represent methylene, hydroxymethylene. acylated hydroxymethylene, carbonyl group or a ketalated carbonyl group and X is H or OH as possessing antitussive and anti-inflammatory activity.

I. Sawa, Maeda and Tada, US. Pat. No. 3,654,280 report the compound having the formula (lower)ac vl,

in which R is H or OH, R' is alkyl, v-u-dimethyl alkyl or a pharmaceutically acceptable acid addition salt or cyclopropylmethyl and F represent the presence or thereof are analgetic agents, narcotic antagonists or inabsence of a double bond as being useful narcotic an termediates in the preparation of such agents. mgon'sts' DISCLOSURE 0F THE INVENTION SUMMARY OF THE INVENTION This invention relates to the total synthesis of new and novel 3,l4,l7-suhstituted-6,7-tetramethylenemor- Compounds having the formula phinans having the formula wherein R is selected from the group comprising H, wherein R is selected from the group comprising H. (lowerkalkyl. 3U (IOWCUQIRYL CH, (H2-C I (Hv (H. ,CH=CH (H. ,CH={

CH, R ('H, (H (H2 ,-(H. AG

#CH I q -CH. fl

Cl CH2 and (lowcr)alkcn \'l, in which R is H or CH R" is scand (lowcrhilkcnyl, in which R is H or CH. R is selected from thc group comprising H. (lo\ver]alkyl lcctetl from the group comprising H, [lowcrmlkyL and cinnamoyl; or a pharmaceutically acceptable acid addition salt thereof.

Drug abuse by thrill-seeking youth or by people looking for an escape from the realities of every day life has become more and more common place in our present society. One class of widely abused drugs are the narcotic analgetics such as codeine. morphine, meperidine, etc. It is because of the high addictive potential of these agents that much time and money are being expended by the pharmaceutical industry and by governments to try and discover and develop new nonaddieting analgetics and/or narcotic antagonists.

It was therefore an object of the present invention to develop low abuse analgetics and a synthesis that would not be dependent upon opium alkaloids as starting materials and yet would be commercially feasible.

The objectives of the present invention have been achieved by the provision of the compounds of formula L and by their total synthesis from the readily available starting material 7-methoxy-3,4-dihydro-2[ lH naphthalenone (lla).

The compounds of the instant invention have the basic tetramcthylenemorphinan nucleus which is numbered and represented by the following plane formula Although there are five asymetric carbons (asterisks) in the tetramcthylenemorphinan molecule, only the configuration at the l4 carbon is significant to this invention since the configurations at all the other asymmetric centers are fixed. The iminoethano system, attached to position 13 and 9, is geometrically constrained to a cis( l,3-diaxial )-fusion. The 6,7- tetramethylene ring is attached trans to the 6,7-carbons with the 6( l) bond cis and the 7 (4') bond trans to the iminoethano system. As such, these racemates can therefore differ only in the configuration of carbon 14. The only variable will be the cis and trans relationship of the l4( 8) carbon substituent to the iminoethano system.

When in the compounds of the present invention the l 4( 8 )-bond is trans to the iminoethano system, we have the l4B-hydroxy-6,7-tetramethylenemorphinans. When the 14(8) bond is cis to the iminoethano system, we have the l4a-hydroxy-6J-tetramethyleneisomorphinans.

The use of a graphic representation ofa 6,7-tctramethylenemorphinan or isomorphinan is meant to include the dl racemic mixture and the resolved d and l isomers thereof.

The compounds of the present invention, the 6,7-tetramethylenemorphinans and 6,7-tetramethyleneisomorphinans, can exist as two optical isomers, the levorotatory and dextrorotatory isomers. The opti cal isomers can be graphically illustrated as:

6 7-tetramethylenemorphinan The present invention embodies the optical isomers in their resolved form.

The optical isomers can be separated and isolated by fractional crystallization of the diastereoisomeric salts formed, for instance, with d or I- tartaric acid or D- (+)-a-bromocamphor sulfonic acid. The levorotatory isomers of the compounds of the present invention are the most preferred embodiments. Other acids commonly used for resolution can be employed.

For the purpose of this disclosure, the term (lower)" is applied to a hydrocarbon radical consisting of l to 6 carbon atoms, e.g., methyl, ethoxy, vinyl, ethinyl, etc. The term (lower)acyl" is an acyl radical of 2 to 6 carbon atoms, e.g., acetyl, propionyl, isobutyryl, etc. The term "pharmaceutically acceptable acid IIa addition salt is defined to include all those inorganic and organic acid salts of the compounds of the instant invention, which salts are commonly used to produce nontoxic salts of medicinal agents containing amine functions. Illustrative examples would be those salts formed by mixing the compounds of formula L with hydrochloric sulfuric, nitric, phosphoric. phosphorus, hydrobromic. maleic, malic, ascorbic, citric, tartaric, pamoic, lauric, stearic, palmitic, oleic, myristic, laurylsulfuric, napthalenesulfonic, linoleic, fumaric or linolenic acid, and the like.

The compounds of the instant invention are prepared by a total synthesis comprising multiple steps. The synthesis is efficient and appears commercially feasible. The process is outlined in the following charts.

ml-LL Example 3 2 Iva VIIa CH O

VIIIa w Ixa N-CO Et A prefcrred embodiment of the present invention is and (lower)alkcnyl, in which R" is H or CH R is sea compound having the formula lected from the group comprising H, (lower)ulkyl,

(lower)ucyl.

O l I? H2 0 wherein R is selected from the group comprising N and cinnamoyl', or a pharmaceutically acceptable acid addition salt thereof.

Another preferred embodiment is the compound having the formula XXXX wherein R is selected from the group comprising CH C E CH, H, CH,CH=CH (lower)alkyl,

and (lower)alkenyl, in which R" is H or CH R is selected from the group comprising H, (lower)alkyl,

in which R" is H or CH and R is H, CH

or a pharmaceutically acceptable acid addition salt thereof.

Another more preferred embodiment is the compounds of formula XXXX wherein R is or CH CH=CH and R is H, CH;; or

or a pharmaceutically acceptable acid addition salt thereof.

Another preferred embodiment is a compound having the formula XXXXI wherein R is selected from the group comprising -CH --C CH,-CH CH=CH H. (lower )alkyl,

and (lower)alkenyl, in which R is H or CH;;. R is selected from the group comprising H, (lower )alkyl.

and cinnanoyl; or a pharmaceutically acceptable salt thereof.

A more preferred embodiment is the compounds of the formula XXXXl wherein R is -CH ---CH=CH -CH CE CH,

Rli

in which R" is H or CH3 R is H. CH;

or a pharmaceutically acceptable acid addition salt thereof.

Another more preferred embodiment is the compounds of formula XXXXl wherein R is or CH- ,CH=CH R is H. CH or or a pharmaceutically acceptable acid addition salt thereof.

Most preferred embodiments are:

l. The compound of formula XXXX wherein R is and R'- is H; or the hydrochloride salt thereof.

2. The compound of formula XXXX wherein R is and R is H; or the hydrochloride salt thereof.

6. The compound of formula XXXXI wherein R is and R is H; or the hydrochloride salt thereof.

7. The compound of formula XXXXI wherein R is CH CH=CH- and R is H; or the hydrochloride salt thereof 8. The compound of formula XXXXl wherein R is H and R is H or methyl; or an acid addition salt wherein R is selected from the group comprising and (lower)alkenyl, in which R is H or CH which process comprises the consecutive steps of A. treating the compound having the formula in which R is (lower)alkyl, with an alkylating or acylating agent having the formula in which W is a radical selected from the group com prising C E. CH, CH=CH (lower)alkyl of 2-5 carbons, and C alkenyl, in which R is H or CH Z is carbonyl or CH: and X is chloro, bromo, or iodo, in an inert organic solvent in the presence of an appropriate base to produce the compound having the formula XXXXIV in which Z. W, and R are as defined above; and when 2 is carbonyl B. treating compound XXXXIV with lithium aluminum hydride, in an organic solvent, to produce the compound having the formula in which R and W are as defined above; and

C. cleaving the ether function of compound XXXXIV or XXXXV by treatment with an agent Selected from the group comprising NaSC H hydrohromic acid, boron tribromide, pyridine hydrochloride or lithium diphenyl phosphide. [C H PLi].

For the purpose of this disclosure the term inert organic solvent means an organic solvent that does not participate in the reaction to the extent that it emerges unchanged from the reaction. Such solvents are methylene chloride, chloroform, diehloroethane, tetrachloromethane, benzene, toluene, ether, ethyl acetate, xylene, tetrahydrofuran, dioxane, dimethylacetamide, dimethylformamide, and the like when an acid halide is employed. When an alkyiation reaction is being performed, the inert solvent used may also include (lower- )alkanols such as methanol, ethanol, n-propanol, isopropanol and the like. The term organic tertiary amine" means a tertiary amine commonly employed as a proton acceptor in acylation reactions. Such amines are tri( lowerlalkylamines, e.g., trimethylamine, triethylamine, and the like. pyridine, dimethylaniline, N- methylpiperidine, and the like.

A preferred embodiment of the present invention is the process of preparing compounds having the formula wherein R' is selected from the group comprising ca CH=CH, 2 I

in which R is H or CH;,; which process comprises the consecutive steps of A. treating the compound having the formula XXXXIIIa in which R is (lower)alkyl, with an acylating agent having the formula in which W is a radical selected from the group comprising 61 I CII4 and C alkyl or alkenyl, in which R is H or CH,,, and X is chloro, bromo or iodo, in an inert organic solvent in the presence of an appropriate base to produce the compound having the formula -CH=CH XXXXIVa in which W and R are as defined above; and

B. treating compound XXXXlVa with lithium aluminum hydride, in an organic solvent, to produce the compound having the fomtula XXXXV a XXXXb wherein R is selected from the group comprising -CH. -CE CH CH- ,CH=CH (lower)alkyl of l to 6 carbons,

CH ,--CH%H,

and C alkenyl; which process comprises the consecutive steps of A. treating the 'compound having the formula XXXXIII! in which R is (lower)alkyl; with an alkylating agent having the formula RX in which R is as above and X is ehloro, bromo or iodo, in an inert organic solvent in the presence of an appropriate base to produce the compound having the formula XXXX IVb in which R and R are as defined above; and

B. cleaving the ether function of compound XXXXlVh by treatment with NaS-C H boron tribromide or pyridine hydrochloride.

Another preferred embodiment of the present invention is a compound having the formula in which R is H or (lower)alkyl of l to 6 carbon atoms.

Another preferred embodiment of the present invention is the compound having the formula in which R is H or (lower)alkyl of 1 to 6 carbon atoms and R is selected from the group comprising H, (lower)alkyl,

in which R" is H or CH An alternative process for the preparation of compounds having the formula in which R is (lower)alkyl and R is a radical of the formula in which R is H or CH which process comprises a. acylating the compound having the formula VII in which W is a radical of the formula VIII in which R and W are as above;

b. oxidizing compound VIII with an excess of a perbenzoic acid, preferably in a ratio of at least I moles of perbcnzoic acid per mole of compound VIII in an organic solvent such as methylene chloride, chloroform, tetrachloroethylene and the like to produce the compounds having the formula which are separated;

c. reducing compound IX or XX, respectively, with at least one mole of lithium aluminum hydride per mole of compound IX or XX but preferably 4-8 moles of lithium aluminum hydride per mole of compound IX or XX, in an inert organic solvent preferably selected from the group comprising diethyl ether, tetrahydrofuran, benzene, toluene, dioxane and the like, with the presence of heat, preferably at about reflux temperature to produce the compounds having the formulas in which R and R are as defined above; and

d. cleaving the ether function of the compounds X by treatment with an agent selected from the group comprising NaS-C H;,, hydrobromic acid, boron tribromide or pyridine hydrochloride to produce compound XI.

All of the compounds of the preferred embodiments herein are novel and valuable for their properties as analgesic and/or narcotic antagonist agents, or as intermediates in the preparation of compounds having these biological activities.

In particular, the compounds having the formula XI are those which possess the most desirable properties, i.c., analgesic and/or narcotic antagonist properties. Some of these compounds also possess antitussive activity, a property generally inherent with analgetic activity in similar series.

It is well known in the narcotic analgesic prior art that it is possible for some compounds to possess both agonist and antagonist properties. An agonist is a compound that imitates a narcotic analgesic and possesses analgetic qualities. An antagonist is a compound that counteracts the analgetic and euphoric properties of a narcotic analgetic. It is possible for a compound to have both properties. A good example of such a compound is cyclazocine.

In vivo testing was conducted on the compounds herein designated as dl-Xlc (racemic mixture), dl-Xld, dl-XIa, l-Xla (levorotatory isomer), d-Xla (dextrorotatory isomer) and dl-Xlb (see examples for structures) to determine their agonist and/or antagonist properties. Table I represents the results of the experiments. The figures reported are the number of milligrams/kilograms of body weight of compound, corrected to read in terms of the free base, that produced an agonist or antagonist effect in 507: of the mice and rats so tested -mi)- TABLE I ED so m kg AGONIST ACTIVITY ANTAGONIST ACTIVITY Phcnyl Ouinone writhing Oxymorphone Oxymorphone Morphine Antag." Test Compounds Mouse Rat Straub Tail Narcosis Rat Tail Flick SC PO SC PO SC PO S/C PO SC PO dLXIc-HCI 5 N.D." N.D. N.D. N.D. ND. N.D. ND. ND. N.D. dl-XIdHC'l -40 N.D. N.D. N.D. 0.63 ND. ND. N.D. 0.045 N.D. zII-XIa-HCI -80 N.D. N.D. N.D. 0.48 49 -03 N.D. 0.040 3.8 l-XIa tzlrtrute 35 N.D. -40 N.D. 0. I 6 23 0.06 0.7 0.030 3.0 rI-Xlu tartrute 40 ND. N.D. N.D. 40 ND. ND. ND. N.D. N.D. dXIb HCI 40 ND. N.D. N.D. 2.57 N.D. ND. N.D. 0.25 6.5 Pentazocine 3.9 36 ll) ND. 12.0 I87 I 90 12.2 82.2 Nalorphine 077 I 0.50 19 l. l4 64 0.58 5.4 0.38 22.l Levallorphan 26.3 N.D. N.D. N.D. 0.29 46 0.32 5.4 0086 I26 (poor dneresponse) Cyelazoeine 0.047 4.0 0.029 5.2 0.8] 24 0. I 2 2.7 0.040 3.7 Nalnxone 40 N.D. 40 ND. 0.09 I3 002 095 0.010 2.7

A 50 per cent reduction in number olphenylquinone induced writhings (Siegmund. E. A. et lI.. Iruc. Sm. Iiiul. & Mal. 95. 729: I957). Antagonism ol' Struub Tail induced by oxymorphone (2 mg/kg. sc.) in 50 per cent of mice.

Antagonism of righting reflex loss induced ol' oxymorphone [l.5 mgl'kg se.) in 50 per cent of rats.

A 50 reduction of analgesic efiect induced by morphine l5 mg/kg. sc. 1 as measured by the mt tail llick procedure (Harris, L. S. and Pier son. A l\'. J. lliru-mm'ul. 6': lit )1. TI'IUNIIL, I43. l4l; I964).

ND. Not done.

It is apparent from the table that compound l-Xla exhibits potent antagonist activity upon parenteral administration. All the compounds of formula XI of the present invention possess varying degrees of potency of the same activity. Similarly, as is inherent in most compounds of this type, the compounds possess some subsidiary anti-tussive and analgesic activity.

The normal oral and parenteral dosage range of the compounds of formula XI in adult humans is in the range of about 0.1 to 50 mg. 3 to 4 times a day depending u on the route of administration and the particular compound administered.

It has been reported in the literature that the compound haloperidol, 4[4-(p-chlorophenyl)-4-hydroxypiperidino]-4-fluorobutyrophenone (Merck Index, 8th Edition, p. 515) has found some experimental use in the alleviation of narcotic addiction withdrawal symptoms. It is therefore an embodiment of the present invention to combine haloperidol with the narcotic antagonists of the instant invention. to produce a product not only preventing narcotic abuse, but at the same time providing supportive therapy in the absence of opiates.

Haloperidol is commonly administered orally in 0.5 to 5.0 mg. 2 to 3 times daily depending upon the severity of the illness. A dose of haloperidol in this range would be administered contemporaneously with an effective dose of the narcotic antagonist to produce the desired result.

Other combinations would include the narcotic antagonists in combination with anti-anxiety agents such as chlorodiazepoxide and diazepam, or phcnothiazines like chlorpromazine, promazine or methotrimeptrazme.

EXAMPLE I 3 IIIa Spiro-[ 7 '-methoxy-trans-hexahydroindane-2.2 '-tetrall '-one] (Illa) A solution of 7-methoxy-l-tetralonc lla 121.0 g, 0.69 mole) and trans-1,2-bis (bromomethyl)cyclohex ane* I880 g, 0.695 mole) in anhydrous benzene 1500 ml) was added, in a fast stream from an addition funnel. to a refluxing mixture of potassium t-butoxide (155.0 g, L38 mole) in anhydrous benzene 1500 ml). The mixture was stirred and refluxed for 24 hours. The above operations were carried out under an atmosphere of nitrogen. After cooling, the mixture was washed with l07c hydrochloric acid and with water. Drying and concentration of the organic phase left an oil which was crystallized from methanol to give Illa as a white solid; g; 69.5%; m.p. l03l04.

* The trunsbis(bromomethyl)cyelohexanc was described by (i. A. Haggis and L. N. Owen. J. ('lmn. Sm. 398. 1953).

Anal. Calcd. for C H O C, 80.24; H, 8.51%. Found: C. 80.53; H, 8.4671

The infrared (IR) and nuclear magnetic resonance (NMR) spectra were consistent with the structure.

EXAMPLE 2 IVa.

Spiro[ l -[3-aminoethyl-l '-hydroxy-7-methoxy-transhexahydroindane-2,2-tetralin] (lVa) A solution of acetonitrile (23 g., 0.56 mole) in dry tetrahydrofuran (THF) (500 ml) was added. under ni trogen, over a period of It) min. to a solution of nbutyllithium (0.564 mole of the commercial I .6M solution in hexane) in dry THF (338 ml) cooled at 78. After a l hour stirring period at 78, a solution of the spirokctone llla I60 g, 0.56 mole) in THF (600 ml) was added as rapidly as possible from an addition funnel. The cooling bath was removed and the solution was stirred for 15 min. Solid lithium hydride (34 g, 0.90 mole) was added in one portion and the resulting mixture was stirred for 3 hours at room temperature. After cooling to 0, the excess of hydride was decomposed by the dropwise addition of water (34 ml), aqueous sodium hydroxide (25.5 ml ofa 20% solution) and again water l 19 ml). The precipitated hydroxides were removed by filtration over Celite and washed with ether (300 ml The combined filtrates were treated with hydrochloric acid (500 ml of a l7r solution) which brought about the separation of an oil (the hydrochloride of lVa is insoluble in water) which crystallized upon cooling. After filtration, the solid was triturated with acetonitrile and dried to give the crude hydrochloride of [Va as a white powder; m.p. 196-200: 140 g; 68%. This crude material was used as such in the next step.

EXAMPLE 3 |Za-B-aminoethyl-S,7.7a,8,9, l 0.1 1.1 111.12.1221- decahydro-2-methoxy-7a. l la-transbenz[a]anthracene (Va).

A mixture of the hydrochloride of lVa (95 g. 0.26 mole cone. hydrochloride acid (200 ml) and benzene (400 ml) was stirred and refluxed for 3 hours under a nitrogen atmosphere. The hot solution was transferred to a separatory funnel and the phases decanted. The aqueous phase was extracted with benzene (200 ml) and the combined benzene layers were diluted with ether (600 ml). Upon cooling, the hydrochloric acid salt of Va separated as colorless crystals. A further crop of solid was obtained by concentration of the filtrates and dilution with ether. Recrystallization from ethanolether gave the pure hydrochloride Va as crystals; m.p. 130; 76%.

Anal. Cale'd for C ,H NOC H -,OH-HCl: C, 70.14; H, 9.21; N. 3.55%. Found: C, 70.51; H. 8.76; N, 3.74%

The IR and NMR spectra were consistent with the structure.

EXAMPLE 4 VIa 9abromo-3-methoxy-6.7-trans-tetramethy1ene hasubanan (Vla The lR and NMR spectra were consistent with the structure.

EXAMPLE VIIa 3-methoxy-6,7-trans-tetramethylene-A"-morphinan (Vlla A mixture of the amine hydrobromide Vla (97.34 g, 0.206 mole) anhydrous sodium bicarbonate (17.3 g. 0.207 mole) and dry dimethylformamide (DMF) (700 ml was heated in an oil bath at 1 10-- 1 for 1.5 hour with vigorous stirring. After cooling. the mixture was poured into a sat. sodium bicarbonate solution (1000 ml) and extracted with benzene (3 X 200 ml). The combined benzene layers were washed with water (5 X 100 ml dried (Na SO and concentrated to leave an oil (63.7 g) (100%) that can be used as such for the next step. The oil was dissolved in ether and treated with an excess of oxalic acid in ether to give a semisolid mass. This was dissolved in a minimum amount of methanol and diluted with a large volume of ether to give the oxalic acid salt of Vlla as a white solid; mp. 186 7; 95%.

The analytical sample was recrystallized from 2- propanol.

Calcd. for C ,H NO C H O C, 69.15; H. 7.32; N, 3.51. Found: C. 68.87; H. 7.53; N. 3.46.

The [R and NMR spectra are consistent with the structure.

EXAMPLE 6 VIIIa l7-cyclopropylcarbonyl-3-methoxy-6,7-transtetramethylene-A-morphinan (Vllla).

Cyclopropylcarbonyl chloride (4.5 g, 0.043 mole) was added dropwise to a stirred and cooled (0) solu tion of the amine Vlla( l 1.62 g. 0.037 mole) and pyridine (3.75 g. 0.047 mole) in methylene chloride (45 ml). After the end of the addition. the mixture was stirred for 10 min at 0 and poured into ice-cold hydrochloric acid (25 ml of a 10'? solution). The aqueous phase was decanted and the organic phase was washed with water (25 ml dried (Na SOfl and concentrated. The residue was recrystallized from ether: 1 1 g; 80%; mp. 186 188 (Vllla).

The analytical sample was prepared in ethyl acetate; m.p. 187-9C.

Calcd. for C -,H -,,NO- C, 79.54; H, 8.28; N, 3.71%. Found1C, 79.33; H, 8.25; N, 3,58%.

The IR and NMR spectra were consistent with the structure.

EXAMPLE 7 Die.

17-cyclopropylcarbonyl-8, l 4a-epoxy-3-methoxy-6,7- trans-tetramethyleneisomorphinan (lXa).

m-Chloroperbenzoic acid (6.15 g of the commercial 85% compound) was added portionwise to a stirred and cooled solution of the unsaturated amide (Vllla) (10.0 g, 0.0255 mole) in methylene chloride (300 ml). After stirring at room temperature for 18 hours, the mixture was washed with a 10% solution of EXAMPLE 8 l 7-cyclopropy1methyl-14a-hydroxy-3-methoxy-6,7- trans-tetramethyleneisomorphinan (Xa).

The amido epoxide lXa l 1.57 g, 0.0295 mole) was added in small portions to a slurry of lithium aluminum hydride (6.0 g, 0.16 mole) in dry THF (100 ml). The mixture was heated under reflux for 1 hour, cooled to (1, and decomposed by the dropwise addition of water (6.0 ml), aqueous sodium hydroxide (4.5 ml of a 207r solution) and water (210 ml). The precipitated hydroxides were removed by filtration over Celite and washed with ether (200 ml). The combined filtrates were extracted with hydrochloric acid (3 X 50 ml of a 10% solution), the combined acidic layers were made alkaline with cone. ammonium hydroxide and extracted with methylene chloride (3 X 100 ml). Drying (Na SO and concentration left an oil which was dissolved in ether and petroleum ether (200 m1, 1:1). After drying with Na SO it was filtered over Celite and the Celite washed with 200 ml of the etherpetroleum ether mixture. Dry HCI was bubbled through the solution and the solid hydrochloride was collected by filtration and washed with etherpetroleum ether; 1 1.26 g mp. 255 260C. (Xa).

Calcd for C H NO HCl: C, 71.83; H, 8.68; N, 3.35%. Found: C, 71.84; H, 8.70; N, 3.27%.

The IR and NMR spectra were consistent with the structure.

EXAMPLE 9 JtIa 17-cyclopropylmethyl-3, l 4a-dihydroxy-6,7'trans-tet ramethyleneisomorphinan (Xla).

A solution of the amine Xa (from 1.75 g of the hydrochloride neutralized with ammonium hydroxide and extracted with methylene chloride) in methylene chloride (40 ml) was added over a period of 1 hour to a stirred and cooled (0) solution of boron tribromide 1.25 ml, 0.019 mole) in methylene chloride (15 ml). After the end of the addition, the mixture was stirred 3 hours at room temperature, cooled to 0 and decomposed with water (15 ml) and cone. ammonium hydroxide (20 ml). After decantation, the aqueous phase was again extracted with methylene chloride (40 m1) and the combined organic layers were washed with a sat. salt solution (15 ml). After drying (Na SO and concentration, the residue was dissolved in ether ml) and treated with hydrochloric acid (20 ml of a 10% solution). The solid hydrochloride of Xa was collected by filtration and recrystallized from methanol-ether; 50%; m. 272273.

Anal. calcd. for C H NO HCI: C, 71.35; H, 8.48; N, 3.47. Found: C, 71.28; H, 8.53; N, 3.27

The IR and NMR spectra was Consistent with the structure.

VIIIb l7-cyclohutyIcarhonyl-3-methoxy-6,7-transtetramethylcne- A"-morphinan (Vlllb).

Substitution in the procedure of Example 6 for the cyclopropylcarhonyl chloride used therein of an equimolar quantity of cyclobutylcarhonyl chloride produced an 85% yield of the title product Xlllh; m.p.

l50 l 52C.

The analytical sample was prepared from ethyl acetate-petroleum ether; m.p. 155 157C.

Calcd for C H NO C, 79.75; H, 8.49: N, 3.57%. Found: C. 80.04; H, 8.44; N, 3,48%.

The IR and NMR spectra were consistent with the structure.

EXAMPLE I l l7-cyclobutylcarbonyl-8, l 40: and l4Bepoxy-3-methoxy-6,7-trans-tetramethyleneisomorphinan and morphinan (IXb and XXb respectively).

Substitution in the procedure of Example 7 for the compound lXa used therein of an equimolar quantity of compound Vlllb produced a mixture of compounds lXh and XXb as an oil. Crystallization from ether gave 4.0 g of lXh as a white solid m.p. l98-200. The liltrates, after standing for 4 days, deposited another crop of lXh (ca 3 g. contaminated with a small amount of XXh). The new filtrates were concentrated in a vacuum and crystallized from ether to afford 6.0 g of XXb as a while solid.

The analytical sample of XXb was prepared from henzene-ether1 m.p. l35l 38.

Calcd. for C ,,H; ,NO;,-l/2C H C, 77.47; H, 8.74; N, 3.15%. Found: C. 77.50; H, 8.12; N, 3.02%.

The IR and NMR spectra of both compounds were consistent with the structure.

EXAMPLE l2 l7-cyclobutylmethyll 4a-hydroxy-3-methoxy-6 7- trans-tetramethyleneisomorphinan (Xb).

Substitution in the procedure of Example 8 for the compound lXa used therein of an equimolar quantity of compound lXb produced the title compound Xb. The hydrochloride was collected and recrystallized from methanol-ether; m.p. 255-265C with decomposition;

Anal. calcd. for C H NO HCI: C, 72.28; H, 8.87; N, 3.24. Found: C, 72.28; H, 8.88; N, 316%.

The IR and NMR spectra were consistent with the structure.

EXAMPLE l3 XIb l7-cyclobutylmethyl-3,-a-dihydroxy-fiJ-trans-tetramethyleneisomorphinan (Xlb).

Substitution in the procedure of Example 9 for the compound Xa used therein on an equimolar quantity of compound Xh produced the title compound Xlb as the hydrochloride salt; m.p. 276277C;

Anal. calcd. for C H NQ 'HCl: C 71.83; H, 8.68; N. 3.35. Found: C, 71.37; H, 8.74; N, 3.12.

The IR and NMR spectra were consistent with the structure.

EXAMPLE l4 -XIa tartrate 1- l 7-cyclopropylmethyl-3, l 4a-dihydroxy-6,7-trans-tetramethyleneisomorphinan (I-Xla )tartrate A boiling solution of d-tartaric acid 1.52 g, 0.0102 EXAMPLE ]7 mole) in methanol (5 ml) was added to a boiling solution of Xla (3.73 g. 0.0102 mole) in methanol (25 ml). After standing at room temperature for 24 hours, the crystals were collected by filtration; 3.0 g, no optical 5 rotation. Repeated recrystallization at high dilution 2 q from methanol gave the following rotations:

l. [01],, -80.7; 2. -84.5; 3. 89; 4. 91.8; 5. -9l.7 0.20 g).

Anal. calcd for C H NO 'l/2C H 'IIZCH OH: l (EH 0 C, 69.40; H, 8.35; N, 3.05%. Found: C, 69.50; H, 8. [2; N, 3.28%.

Xd EXAMPLE l l 7-cyclopropylmethyll 4B-hydroXy-3-methoxy-6.7-

CH2 1 trans-tetramethylenemorphinan (Xd).

\OH The ether filtrates from the preparation of lXa (Example 7) were concentrated and chromatographed HO 1 over silica gel (500 g) eluting with 3071 ether in petroleum ether and collecting 50 ml fractions. Fractions l Q' 13171113118 to 4 gave traces of starting material Vllla. Fractions 5 to ID gave the isomorphinan isomer lXa, fractions l l-l9 gave 2.55 g (20% overall) of the B-isomer. l7- cyclopropylcarbonyl-S, l 4B-epoxy-3-methoxy-6J- trans-tetramethylene morphinan, as a semi-solid (lXd). An equimolar quantity of the crude semi-solid (lXd) was substituted in the procedure of Example 8 for the compound lXa used therein to produce the title com- The d-isomel' was P p like the l'isomel' V pound Xd which was collected as the hydrochloride in ample 14) starting with l-tartaric acid and the free base the form of COIOHeSS crystals; 26] g obtained from the filtrates of crystallization of the l- (mehand emery isomer. It was isolated as the half salt of l-tartaric acid;

[01],, 96.73 (methanol); m.p. 195 200 (1.

Calcd. for C H NO-y1/2C H,;O -l/2CH OH: C, 69.40; H, 8.35; N, 3.05%. Found: C, 69.32; H, 8.06; N, 3.37%.

EXAMPLE l6 dl 7-Cyclopropylmethyl'3, l 4a-dihydroxy-6,7-trans- 30 tetramethyleneisomorphinan (d-Xla )tartrate.

EXAMPLE 1 8 l7-cyclopromethyl-3, l4B-dihydroxy-6,7-trans-tetramethylenemorphinan (Xld).

The free amine compound Xd (2.47 g.. 0.0065 mole) prepared by neutralization of the hydrochloride salt was O-demethylated with boron tribromide (LS ml.,

Substitution in the procedure of Example 8 for the 0.016 mole) in methylene chloride (20 ml.) in accorepoxide lXa used therein of an equimolar quantity of dance with the procedure found in Example 9. The title l7-cyclobutylmethyll 4Bhydroxy-3-methoxy-6,7- trans-tetramethylenemorphinan (Xc).

XXb (obtained in Example 1 1 produced the title comproduct lXd was isolated as the hydrochloride salt: 1.5 pound Xc as a white solid; mp. 92-94 (ethanol). g.; 42%; m.p. 271-274C.

Anal. Calcd. for C H Noz C, 78.94; H, 9.43; N, Anal. calcd for C H NO 'HCl: C, 7l.35; H. 8.48; 3.54%. Found: C, 78.67; H. 9.54; N, 3.43%. N, 3.47. Found: C, 7|.06; H, 8.59; N, 3.40.

The IR and NMR spectra were consistent with the The IR and NMR spectra were consistent with the EXAMPLE w N-CHZ-O l7-cyclobutylmethyl-3. l 4B-dihydroxy-6.7-trans-tetramethylenemorphinan (Xlc Substitution in the procedure of Example 9 for the compound Xa used therein of an equimolar quantity of Xc produced an oil (Xlc) which was dissolved in ether, filtered over Celite to remove some insoluble material and treated with an excess of anhydrous hydrogen chloride. The white solid hydrochloric acid salt of Xlc was collected by filtration and recrystallized in ethanolether; m.p. 264-274 d.; 67%.

Anal. calcd. for C -,H -,;,NO -HCI: 7l.83; H, 8.68; N, 3.35%. Found: C, 71.90; H. 8.72; N 3,23%.

The IR and NMR spectra were consistent with the structure.

EXAMPLE 20 3-methoxy-6.7-trans-tetramethylenel 7- trifluoroaeetyl-A*-morphinan (Xlla Trifluoroacetic anhydride (80 ml, 056 mole) was added as rapidly as possible, keeping the temperature at to an ice-cooled, vigorously. stirred mixture of the amine Vlla (30.25 g, 0.095 mole) and anhydrous Na cO 60 g. 0.7 mole) in anhydrous ether l60 ml). The mixture was stirred vigorously at room temperature for 1 hour, ice was added at hydrolyze the excess of anhydride and the mixture was decanted. the ether phase washed with water. dried and concentrated to leave 37 g of an oily residue. Chromatography of this oil on silica gel (900 g) gave 294) g (7771) (etherpetroleum ether. 1:4) of pure oil (Xlla) which was used as such for the next step.

The IR and NMR were consistent with the structure.

EXAMPLE 21 XIIIa 8. l4a-epoxy-3-methoxy-6,7-trans-tetramethylenel 7- trifluoraeetylisomorphinan (Xllla).

EXAMPLE 22 XIVa 8, l 4a-epoxy-S-methoxy-6,7-trans-tetramethyleneisomorphinan (XlVa).

A mixture of Xllla (5.5 g. 0.013 mole) and sodium borohydride (0.495 g, 0.0l3 mole) in absolute ethanol (30 ml) was heated under reflux for 10 min. After cooling the mixture was poured into dilute hydrochloric acid (25 ml ofa 10% solution) and the solution washed with ether. The aqueous layer was made basic with cone. ammonium hydroxide and extracted with ether (3 X 20 ml). The combined ether layers were dried over Na SO, and concentrated to give 5.2 g of an oil identified as compound XlVa which was used as such in the next step.

The IR and NMR spectra were consistent with the structure.

EXAMPLE 23 XVa l4a-hydroxy-3-methoxy-6. 7-trans-tetramethyleneisomorphinan (XVa).

The amino epoxide XlVa (5.2 g, 0.016 mole) in THF (50 ml) was added dropwise to a stirred suspension of LiAlH. (3.0 g. 0.079 mole) in THF (25 ml). The mixture was heated under reflux for 1 hour, cooled and decomposed with water (3 ml), sodium hydroxide (2.25 ml ofa 20% aqueous solution) and water 10.5 ml). Filtration over Celite and concentration left a colorless oil which was dissolved in ether 100 ml) and treated with an excess of a saturated hydrogen chloride solution in ether. The solid was collected by filtration and recrystallized from ethanol-ether; 2.90 g (50% m.p. 282285C. of title compound XVa.

Anal. calcd. for C H NO HCl-l/2H- ,O: C, 67.63; H, 8.38; N. 3.76%. Found: C. 67.67; H, 8.50; N. 3.70%.

EXAMPLE 24 l 7-al1yll 4oz-hydroxy-3-methoxy-6,7-trans-tetramethyleneisomorphinan (Xe).

A mixture of the aminoalcohol XVa (from 2.20 g, 0.0065 mole of the HCl salt, Na CO and CH Cl triethylamine (2.7 g, 0.027 mole) and allyl bromide (l.l g. 0.01 mole) in absolute ethanol (25 ml) was heated under reflux for 18 hours. After cooling, the mixture was poured into Na CO (100 ml of a l% solution) and extracted with methylene chloride (3 X l ml). Drying and concentration of the combined methylene chloride extract left an oil which was dissolved in ether and filtered over Celite. An excess of a saturated solution of hydrogen chloride in ether was added to the filtrates. The solid hydrochloride salt was collected by liltration and recrystallized from ethanol-ether; mp. l92-4 (Xe).

Anal. calcd. for C H NO 'HCl'H O: C. 68.30; H. 8.59: N. 3.32%. Found: C. 67.58; H, 8.50; N. 3.35%.

EXAMPLE 25 l7-allyl-3, l 40z-dihydroxy-6.7-trans-tetramethyleneisomorphinan (Xle).

g of the HCI salt, NH.,OH and CH Cl in DMF (20 ml) was added to the above solution and the mixture was stirred and refluxed for 2 hours. cooled, poured into ice-water (50 ml), acidified to pH6 with hydrochloric acid and made basic with ammonium hydroxide. it was extracted with benzene (4 X 50 ml), dried over Na SO and concentrated. The residual oil was dissolved in ether and treated with an excess of a solution of hydrogen chloride in ether. The solid hydrochloride salt was collected by filtration and recrystallized from ethanolether; m.p. 275 280C.

Anal. calc'd. for C -,H,-, NO 'HCl'l/2H O: C, 69.24; H. 8.34; N. 3.51% Found: C, 69.40; H, 8.25; N, 3.53%.

EXAMPLE 26 ll 7'cyclopropylmethyl-3, l4a-dihydro-6,7-trans-tctramethyleneisomorphinan 3-( 4'-nicotinoate To a solution of 0.002 mole of compound l-Xla in 3 ml of pyridine is added 0.0025 mole of 4-nicotinoyl chloride hydrochloride. The mixture is refluxed for one hour and the solvents evaporated. The residue is partitioned between ether and dilute ammonium hydroxide, the ether layer separated, washed with water, dried over anhydrous sodium sulfate, filtered and evaporated in vacuo to produce the desired nicotinoyl ester.

EXAMPLE 27 I- l 7-eyclopropylmethyl-3, l 4a-dihydroxy-6.7-trans-tetramethyleneisomorphinan 3( 3 '-nicotinoate-n-oxide Substitution in the procedure of Example 26 for the 4-nieotinoyl chloride hydrochloride used therein of an equimolar quantity of 3-nicotinoyl chloridc-N-oxide produces the desired ester.

EXAMPLE 28 3-monomcthoxymcthyl ether of ll 7-cyclopropylmethyl fl, l4a-hydroxy-6.7-trans-tetramethyleneisomorphinan.

(hloromethylmethyl ether (0.01 mole) is placed into l0 ml of dry dimethylformamide and the resulting solution is added to 0.0075 mole of compound l-Xla dissolved in 20 ml of dry diemthylformamide. Anhydrous 

1. COMPOUND HAVING THE FORMULA
 2. A compound of claim 1 having the formula
 3. A compound of claim 2 wherein R1 is -CH2-CH CH2, -CH2-C*CH,
 4. A compound of claim 2 wherein R1 is
 5. The compound of claim 2 wherein R1 is
 6. The compound of claim 2 wherein R1 is
 7. The compound of claim 2 wherein R1 is -CH2-CH CH2 and R2 is H; or the hydrochloride salt thereof.
 8. The compound of claim 2 wherein R1 is H and R2 is H or methyl; or an acid addition salt thereof.
 9. A compound of claim 1 having the formula
 10. A compound of claim 9 wherein R1 is -CH2-CH CH2 -CH2-C*CH,
 11. A compound of claim 9 wherein R1 is
 12. The compound of claim 9 wherein R1 is
 13. The compound of claim 9 wherein R1 is
 14. The compound of claim 9 wherein R1 is -CH2-CH CH2 and R2 is H; or the hydrochloride salt thereof.
 15. The compound of claim 9 wherein R1 is H and R2 is H or methyl; or an acid addition salt thereof.
 16. The levorotatory isomers of the compounds of claim
 2. 17. The dextrorotatory isomers of the compounds of claim
 2. 18. The levorotatory isomers of the compounds of claim
 9. 19. The dextrorotatory isomers of the compounds of claim
 9. 20. A compound having the formula
 21. A compound having the formula 